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Mechanism of in vitro percutaneous absorption enhancement of carvedilol by penetration enhancers.
- Source :
-
Pharmaceutical development and technology [Pharm Dev Technol] 2008; Vol. 13 (6), pp. 533-9. - Publication Year :
- 2008
-
Abstract
- The effect of penetration enhancers like tulsi (basil) oil, eucalyptus oil, clove oil, black cumin oil, oleic acid and Tween 80 on the percutaneous absorption of model lipophilic drug-carvedilol was investigated using excised rat abdominal skin. Transdermal flux, permeability coefficient and enhancement factor were calculated for each penetration enhancer. Black cumin oil (5% v/v) was selected on the basis of its highest enhancement in permeation and was evaluated further for its mode of action using DSC, FTIR and histological studies. The results indicated that the oil shows its action by extraction of lipids from stratum corneum as well as by loosening the hydrogen bonds between ceramides subsequently leading to fluidization of the lipid bilayer.
- Subjects :
- 2-Propanol pharmacology
Animals
Calorimetry, Differential Scanning
Carbazoles administration & dosage
Carvedilol
Clove Oil pharmacology
Epidermis drug effects
Epidermis metabolism
Epidermis pathology
Eucalyptus chemistry
Female
In Vitro Techniques
Nigella sativa chemistry
Ocimum
Oleic Acid pharmacology
Plant Oils pharmacology
Polysorbates pharmacology
Propanolamines administration & dosage
Rats
Rats, Wistar
Skin metabolism
Spectroscopy, Fourier Transform Infrared
Transition Temperature drug effects
Vasodilator Agents administration & dosage
Vasodilator Agents pharmacokinetics
Adjuvants, Pharmaceutic pharmacology
Carbazoles pharmacokinetics
Propanolamines pharmacokinetics
Skin drug effects
Skin Absorption drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1097-9867
- Volume :
- 13
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Pharmaceutical development and technology
- Publication Type :
- Academic Journal
- Accession number :
- 18720242
- Full Text :
- https://doi.org/10.1080/10837450802309646