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Systemic antibiotics and tooth loss in periodontal disease.
- Source :
-
Journal of dental research [J Dent Res] 2008 Sep; Vol. 87 (9), pp. 871-6. - Publication Year :
- 2008
-
Abstract
- Systemic antibiotics have been recommended for the treatment of destructive periodontal disease. Our goal was to relate antibiotic use for medical or dental reasons to subsequent tooth loss in a cohort of 12,631 persons with destructive periodontal disease. After adjustment for age, smoking, and other confounders, the dispensing of antibiotics for 1-13 days, 14-20 days, or 21 or more days was not associated with reduced tooth loss [Adjusted rate ratio (RR) = 1.0; 95% Confidence Interval (CI) = 0.8-1.1; RR = 1.2; 95% CI = 0.9-1.4, and RR =1.2, 95% CI =1.0-1.3, respectively]. Numerous subgroup analyses were consistent with these overall null findings, with two exceptions: Longer courses of tetracyclines were associated with reduced tooth loss among persons receiving periodontal care, and penicillin was associated with reduced tooth loss among persons with more severe disease. Long-term, larger randomized trials are needed to provide evidence that antibiotics reduce tooth loss when used in the management of destructive periodontal disease.
- Subjects :
- Anti-Bacterial Agents classification
Case-Control Studies
Chi-Square Distribution
Cohort Studies
Drug Administration Schedule
Female
Follow-Up Studies
Humans
Male
Middle Aged
Periodontal Diseases drug therapy
Periodontal Diseases immunology
Retrospective Studies
Severity of Illness Index
Therapeutics
Tooth Loss immunology
Tooth Loss prevention & control
Anti-Bacterial Agents therapeutic use
Periodontal Diseases complications
Tooth Loss complications
Subjects
Details
- Language :
- English
- ISSN :
- 0022-0345
- Volume :
- 87
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of dental research
- Publication Type :
- Academic Journal
- Accession number :
- 18719216
- Full Text :
- https://doi.org/10.1177/154405910808700916