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Coupling of L-type Ca2+ channels to KV7/KCNQ channels creates a novel, activity-dependent, homeostatic intrinsic plasticity.
- Source :
-
Journal of neurophysiology [J Neurophysiol] 2008 Oct; Vol. 100 (4), pp. 1897-908. Date of Electronic Publication: 2008 Aug 20. - Publication Year :
- 2008
-
Abstract
- Experience-dependent modification in the electrical properties of central neurons is a form of intrinsic plasticity that occurs during development and has been observed following behavioral learning. We report a novel form of intrinsic plasticity in hippocampal CA1 pyramidal neurons mediated by the KV7/KCNQ and CaV1/L-type Ca2+ channels. Enhancing Ca2+ influx with a conditioning spike train (30 Hz, 3 s) potentiated the KV7/KCNQ channel function and led to a long-lasting, activity-dependent increase in spike frequency adaptation-a gradual reduction in the firing frequency in response to sustained excitation. These effects were abolished by specific blockers for CaV1/L-type Ca2+ channels, KV7/KCNQ channels, and protein kinase A (PKA). Considering the widespread expression of these two channel types, the influence of Ca2+ influx and subsequent activation of PKA on KV7/KCNQ channels may represent a generalized principle in fine tuning the output of central neurons that promotes stability in firing-an example of homeostatic regulation of intrinsic membrane excitability.
- Subjects :
- Animals
Cyclic AMP-Dependent Protein Kinases metabolism
Data Interpretation, Statistical
Electrophysiology
Hippocampus cytology
Hippocampus physiology
Immunohistochemistry
In Vitro Techniques
Ligands
Male
Patch-Clamp Techniques
Pyramidal Cells physiology
Rats
Rats, Inbred F344
Reverse Transcriptase Polymerase Chain Reaction
Calcium Channels, L-Type physiology
Homeostasis physiology
KCNQ Potassium Channels physiology
Neuronal Plasticity physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3077
- Volume :
- 100
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of neurophysiology
- Publication Type :
- Academic Journal
- Accession number :
- 18715900
- Full Text :
- https://doi.org/10.1152/jn.90346.2008