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Coupling of L-type Ca2+ channels to KV7/KCNQ channels creates a novel, activity-dependent, homeostatic intrinsic plasticity.

Authors :
Wu WW
Chan CS
Surmeier DJ
Disterhoft JF
Source :
Journal of neurophysiology [J Neurophysiol] 2008 Oct; Vol. 100 (4), pp. 1897-908. Date of Electronic Publication: 2008 Aug 20.
Publication Year :
2008

Abstract

Experience-dependent modification in the electrical properties of central neurons is a form of intrinsic plasticity that occurs during development and has been observed following behavioral learning. We report a novel form of intrinsic plasticity in hippocampal CA1 pyramidal neurons mediated by the KV7/KCNQ and CaV1/L-type Ca2+ channels. Enhancing Ca2+ influx with a conditioning spike train (30 Hz, 3 s) potentiated the KV7/KCNQ channel function and led to a long-lasting, activity-dependent increase in spike frequency adaptation-a gradual reduction in the firing frequency in response to sustained excitation. These effects were abolished by specific blockers for CaV1/L-type Ca2+ channels, KV7/KCNQ channels, and protein kinase A (PKA). Considering the widespread expression of these two channel types, the influence of Ca2+ influx and subsequent activation of PKA on KV7/KCNQ channels may represent a generalized principle in fine tuning the output of central neurons that promotes stability in firing-an example of homeostatic regulation of intrinsic membrane excitability.

Details

Language :
English
ISSN :
0022-3077
Volume :
100
Issue :
4
Database :
MEDLINE
Journal :
Journal of neurophysiology
Publication Type :
Academic Journal
Accession number :
18715900
Full Text :
https://doi.org/10.1152/jn.90346.2008