Back to Search
Start Over
Vitamins B2, B6, and B12 and risk of new colorectal adenomas in a randomized trial of aspirin use and folic acid supplementation.
- Source :
-
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2008 Aug; Vol. 17 (8), pp. 2136-45. - Publication Year :
- 2008
-
Abstract
- Background: Folate, other vitamin B cofactors, and genes involved in folate-mediated one-carbon metabolism all may play important roles in colorectal neoplasia. In this study, we examined the associations between dietary and circulating plasma levels of vitamins B(2), B(6), and B(12) and risk colorectal adenomas.<br />Methods: The Aspirin/Folate Polyp Prevention Study is a randomized clinical trial of folic acid supplementation and incidence of new colorectal adenomas in individuals with a history of adenomas (n = 1,084). Diet and supplement use were ascertained through a food frequency questionnaire administered at baseline. Blood collected at baseline was used to determine plasma B-vitamin levels. We used generalized linear regression to estimate risk ratios (RR) and 95% confidence intervals (95% CI) as measures of association.<br />Results: We found a borderline significant inverse association with plasma B(6) [pyridoxal 5'-phosphate (PLP)] and adenoma risk (adjusted RR Q4 versus Q1, 0.78; 95% CI, 0.61-1.00; P(trend) = 0.08). This association was not modified by folic acid supplementation or plasma folate. However, the protective association of PLP with adenoma risk was observed only among subjects who did not drink alcohol (P(interaction) = 0.03). Plasma B(2) (riboflavin) was inversely associated with risk of advanced lesions (adjusted RR Q4 versus Q1, 0.51; 95% CI, 0.26-0.99; P(trend) = 0.12). No significant associations were observed between adenoma risk and plasma vitamin B(12) or dietary intake of vitamin B(2) and B(6). When we examined specific gene-B-vitamin interactions, we observed a possible interaction between methylenetetrahydrofolate reductase -C677T and plasma B(2) on risk of all adenomas.<br />Conclusion: Our results suggest that high levels of PLP and B(2) may protect against colorectal adenomas.
- Subjects :
- Adenoma epidemiology
Adenoma genetics
Alcohol Drinking adverse effects
Chemoprevention
Colorectal Neoplasms epidemiology
Colorectal Neoplasms genetics
Double-Blind Method
Female
Folic Acid blood
Genotype
Humans
Incidence
Linear Models
Male
Methylenetetrahydrofolate Reductase (NADPH2) genetics
Middle Aged
Neoplasm Recurrence, Local prevention & control
Poisson Distribution
Polymorphism, Genetic
Riboflavin blood
Risk
Surveys and Questionnaires
Vitamin B 12 blood
Vitamin B 6 blood
Adenoma prevention & control
Aspirin therapeutic use
Colorectal Neoplasms prevention & control
Folic Acid therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1055-9965
- Volume :
- 17
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 18708408
- Full Text :
- https://doi.org/10.1158/1055-9965.EPI-07-2895