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Impact of escitalopram treatment on Quality of Life Enjoyment and Satisfaction Questionnaire scores in major depressive disorder and generalized anxiety disorder.
- Source :
-
International clinical psychopharmacology [Int Clin Psychopharmacol] 2008 Sep; Vol. 23 (5), pp. 276-86. - Publication Year :
- 2008
-
Abstract
- Administration of the same Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q) in major depressive disorder (MDD) and in generalized anxiety disorder (GAD) before and after treatment allowed us to compare quality of life enjoyment and satisfaction in these two disorders and to compare outcome based on symptoms versus functioning. Q-LES-Q and symptom-specific Montgomery-Asberg Depression Rating Scale (MADRS) and Hamilton Anxiety Scale (HAMA) data from eight randomized, 8-week, double-blind, placebo-controlled clinical trials with escitalopram were used. MDD (n=1,140) or GAD (n=1,045) patients report a substantial degree of quality of life enjoyment and satisfaction impairment (baseline scores 64% and 76% of community norm, respectively). Treatment resulted in statistically and clinically significant improvement in quality of life enjoyment and satisfaction. The improvement was greater in patients treated with escitalopram than with placebo. In MDD, the majority of remitters (MADRS<or=12) reached 'normal' quality of life enjoyment and satisfaction levels, whereas in GAD, 67% of remitters (HAMA<or=7) reached 'normal' quality of life, enjoyment, and satisfaction. A strong correlation between the symptom-specific scales and the Q-LES-Q was observed. These analyses suggest that remission with scores of 6 on the MADRS and 5 on the HAMA correspond with a quality of life enjoyment and satisfaction found in community comparison patients (Q-LES-Q score of 58+/-10%). Treatment with escitalopram results in a significant improvement of quality of life enjoyment and satisfaction in patients with MDD or GAD. Both response and remission in patients with GAD and remission in patients with MDD are correlated with a 'normal' quality of life enjoyment and satisfaction.
- Subjects :
- Adolescent
Adult
Aged
Antidepressive Agents adverse effects
Citalopram adverse effects
Double-Blind Method
Female
Humans
Longitudinal Studies
Male
Middle Aged
Patient Satisfaction
Surveys and Questionnaires
Treatment Outcome
Antidepressive Agents therapeutic use
Anxiety Disorders drug therapy
Anxiety Disorders psychology
Citalopram therapeutic use
Depressive Disorder, Major drug therapy
Depressive Disorder, Major psychology
Quality of Life
Subjects
Details
- Language :
- English
- ISSN :
- 0268-1315
- Volume :
- 23
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- International clinical psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 18703937
- Full Text :
- https://doi.org/10.1097/YIC.0b013e328303ac5f