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The HTLV-1 Tax interactome.
- Source :
-
Retrovirology [Retrovirology] 2008 Aug 14; Vol. 5, pp. 76. Date of Electronic Publication: 2008 Aug 14. - Publication Year :
- 2008
-
Abstract
- The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins. In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.
- Subjects :
- Cell Cycle Proteins genetics
Cell Cycle Proteins metabolism
Gene Products, tax chemistry
Gene Products, tax genetics
HTLV-I Infections physiopathology
HTLV-I Infections virology
Human T-lymphotropic virus 1 chemistry
Human T-lymphotropic virus 1 genetics
Humans
Nuclear Pore Complex Proteins genetics
Nuclear Pore Complex Proteins metabolism
Protein Binding
Protein Structure, Tertiary
Signal Transduction
Transcription Factors genetics
Transcription Factors metabolism
Transcriptional Activation
Gene Products, tax metabolism
HTLV-I Infections metabolism
Host-Pathogen Interactions
Human T-lymphotropic virus 1 enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 1742-4690
- Volume :
- 5
- Database :
- MEDLINE
- Journal :
- Retrovirology
- Publication Type :
- Academic Journal
- Accession number :
- 18702816
- Full Text :
- https://doi.org/10.1186/1742-4690-5-76