Back to Search
Start Over
Clonality and HPV infection analysis of concurrent glandular and squamous lesions and adenosquamous carcinomas of the uterine cervix.
- Source :
-
American journal of clinical pathology [Am J Clin Pathol] 2008 Sep; Vol. 130 (3), pp. 389-400. - Publication Year :
- 2008
-
Abstract
- We analyzed the clonality and human papillomavirus (HPV) infection status of concurrent glandular and squamous lesions and adenosquamous carcinomas of the uterine cervix to clarify their histogenesis. The glandular and squamous components were clonally different from each other in 7 informative concurrent lesions. HPV was episomal in 2 polyclonal glandular dysplasias (GDs). HPV was in a mixed integrated-episomal form in a monoclonal GD, an adenocarcinoma in situ, and an adenocarcinoma. Both tumor components were monoclonal in origin in 6 adenosquamous carcinomas, with identical patterns of X-chromosomal inactivation and types and physical status of HPV. These results imply that the concurrent glandular and squamous lesions are formed separately, whereas adenosquamous carcinoma is more likely to be a combination tumor of monoclonal origin, and that integration of HPV has an important role in the progression from polyclonal GD through monoclonal expansion to adenocarcinoma in situ and adenocarcinoma.
- Subjects :
- Adenocarcinoma immunology
Adenocarcinoma pathology
Antibodies, Viral analysis
Carcinoma, Adenosquamous immunology
Carcinoma, Squamous Cell immunology
Carcinoma, Squamous Cell pathology
Cervix Uteri immunology
Endometrial Neoplasms immunology
Female
Human papillomavirus 16 isolation & purification
Human papillomavirus 18 isolation & purification
Humans
Papillomavirus Infections immunology
Polymerase Chain Reaction
Uterine Cervical Dysplasia immunology
Uterine Cervical Dysplasia pathology
Adenocarcinoma virology
Carcinoma, Adenosquamous virology
Carcinoma, Squamous Cell virology
Cervix Uteri pathology
Cervix Uteri virology
Endometrial Neoplasms virology
Papillomavirus Infections pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9173
- Volume :
- 130
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- American journal of clinical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 18701412
- Full Text :
- https://doi.org/10.1309/ERR93AF840YYNDRQ