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Hepatotoxicity in patients prescribed efavirenz or nevirapine.
- Source :
-
European journal of medical research [Eur J Med Res] 2008 Jul 28; Vol. 13 (7), pp. 343-8. - Publication Year :
- 2008
-
Abstract
- Aim: For several years Nonnucleoside reverse transciptase inhibitors (NNRTIs) in antiretroviral therapy have been associated with hepatic side effects. Particularly the hepatotoxic potential of Nevirapine is well analysed today. We performed a prospective, multicenter study to compare the hepatotoxicity of Efavirenz (EFV) with that of Nevirapine (NVP) and to investigate further risk factors.<br />Material and Methods: The study included HIV-1-infected patients from five clinics and private medical practices in southwestern Germany who initiated an antiretroviral therapy with NVP or EFV between July 1998 and December 2001. Among 296 patients in total, 151 received EFV and 145 received NVP. Laboratory tests during the course of treatment included liver enzymes, HIV-RNA and CD4 cell-count. Additionally, signs of clinical hepatitis were recorded. Hepatotoxicity was graded in the manner of Sulkowsky et al. (2000), who used a scale modified from that of the AIDS Clinical Trials Group.<br />Results: Hepatitis C virus and hepatitis B virus were detected in 10.1% and 4.1% of patients, respectively. The overall rate of severe hepatotoxicity (grade 3 to 4 elevations in aspartate aminotransferase and/or alanine aminotransferase) was 2 of 151 (1.3%) in patients prescribed EFV and 3 of 145 (2.1%) in patients prescribed NVP. Mild-to-moderate hepatotoxicity (grade 2 elevation) was observed in 6.0% (EFV) and 3.4% (NVP) of patients. Incidence of mild-to-moderate and severe hepatotoxicity did not differ significantly between the study groups. 3 of 14 patients (2.1%) with grade 2 elevation of liver enzymes (LEE) and 4 of 5 patients (80%) with grade 3 to 4 LEE were symptomatic. Only risk factor for the development of mild-to-moderate hepatotoxicity was hepatitis C coinfection.<br />Conclusion: Increases of liver enzymes during therapy with NVP or EFV are not unusual, but are mostly mild-to-moderate and asymptomatic. LEE occurs just as frequent in patients prescribed EFV as in patients prescribed NVP.
- Subjects :
- Adult
Alkynes
CD4-Positive T-Lymphocytes metabolism
Cyclopropanes
Female
HIV Infections complications
Hepacivirus metabolism
Hepatitis B virus metabolism
Humans
Liver enzymology
Male
Middle Aged
Reverse Transcriptase Inhibitors administration & dosage
Reverse Transcriptase Inhibitors adverse effects
Risk Factors
Benzoxazines adverse effects
Chemical and Drug Induced Liver Injury
HIV Infections drug therapy
Liver drug effects
Nevirapine adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0949-2321
- Volume :
- 13
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- European journal of medical research
- Publication Type :
- Academic Journal
- Accession number :
- 18700192