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The effects of body mass index on graft survival in adult recipients transplanted with single pediatric kidneys.
- Source :
-
American journal of nephrology [Am J Nephrol] 2009; Vol. 29 (2), pp. 94-101. Date of Electronic Publication: 2008 Aug 11. - Publication Year :
- 2009
-
Abstract
- Background: There is insufficient data on the impact of recipient body mass index (BMI) on the long-term graft survival of adult patients transplanted with single pediatric kidneys.<br />Methods: We performed a retrospective analysis of adult patients transplanted with single pediatric kidneys at our center. The recipients were classified into 2 groups: group 1 (BMI > or =30) and group 2 (BMI <30). Donor/recipient demographics, postoperative outcomes and survival rates were compared between the 2 groups.<br />Results: There was no significant difference in donor/recipient demographics between the 2 groups. In group 1, the death-censored graft survival (DCGS) at 1, 3 and 5 years was 90% at all 3 time points, and in group 2 it was 86, 68 and 60%, respectively (p = 0.05). The mean glomerular filtration rate (with standard deviation in parentheses) at 1, 3 and 5 years was, respectively, 55 (15), 59 (19) and 55 (28) ml/min for group 1, compared to 65 (28), 69 (23) and 67 (20) ml/min in group 2 (p = NS). Multivariate analysis revealed a hazard ratio of 5.12 (95% confidence interval 1.06-24.7; p = 0.04) for graft loss in nonobese patients when compared to obese patients. Obese patients had an increased risk for acute rejections within the first month of transplant (p = 0.02).<br />Conclusion: Patients with a BMI > or =30 transplanted with single pediatric kidneys have better DCGS rates when compared to nonobese patients.<br /> (Copyright (c) 2008 S. Karger AG, Basel.)
- Subjects :
- Adult
Age Factors
Body Weight
Child
Female
Follow-Up Studies
Graft Rejection drug therapy
Humans
Immunosuppressive Agents therapeutic use
Kaplan-Meier Estimate
Male
Middle Aged
Postoperative Complications epidemiology
Proportional Hazards Models
Proteinuria epidemiology
Retrospective Studies
Risk Factors
Body Mass Index
Delayed Graft Function epidemiology
Graft Rejection epidemiology
Graft Survival
Kidney Transplantation statistics & numerical data
Obesity epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1421-9670
- Volume :
- 29
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- American journal of nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 18689988
- Full Text :
- https://doi.org/10.1159/000151293