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[Primary natural killer/T cell lymphoma of the lung: two cases report and clinical analysis].
- Source :
-
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases [Zhonghua Jie He He Hu Xi Za Zhi] 2008 Feb; Vol. 31 (2), pp. 120-4. - Publication Year :
- 2008
-
Abstract
- Objective: To describe the clinical and pathological features of primary NK/T cell lymphoma of the lung.<br />Methods: Two cases of primary NK/T cell lymphoma of the lung were reported, and the clinical, radiological and pathological characteristics of the disease were discussed with literature review of 3 cases.<br />Results: Most patients presented with fever, cough and dyspnea, and antibiotics were ineffective. Radiographic findings included solitary or multiple nodules and consolidation, unilateral orbilateral pleural effusions (4/5), without hilar or mediastinal adenopathy. Ebstein-Barr virus was positive in cases patients (3/5). Histopathology revealed a great deal of abnormal lymphocyte infiltration, which were angio-centric with marked tissue putrescence and angio-destruction. Immunophenotyping showed CD56(+), CD3(+), perform (+), T-cell intracytoplasmic antigen-1(+) and/or GranB(+), but CD20(-). Most patients died of respiratory failure in half a year (4/5).<br />Conclusion: Primary NK/T cell lymphoma of the lung is rare, but should be considered when patients present with lung shadows and fever non-responsive to antibiotics, decreased WBC and increased LDH.
Details
- Language :
- Chinese
- ISSN :
- 1001-0939
- Volume :
- 31
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
- Publication Type :
- Academic Journal
- Accession number :
- 18683784