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Clinical trials update from Heart Rhythm 2008 and Heart Failure 2008: ATHENA, URGENT, INH study, HEART and CK-1827452.
- Source :
-
European journal of heart failure [Eur J Heart Fail] 2008 Sep; Vol. 10 (9), pp. 917-20. Date of Electronic Publication: 2008 Aug 03. - Publication Year :
- 2008
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Abstract
- This article provides information and a commentary on trials relevant to the pathophysiology, prevention and treatment of heart failure, presented at the Heart Rhythm Society meeting in San Francisco, USA and the Heart Failure Association meeting of the European Society of Cardiology which was held in Milan, Italy in June 2008. Unpublished reports should be considered as preliminary data, as analyses may change in the final publication. The ATHENA study showed that dronedarone reduced the incidence of the composite outcome of cardiovascular hospitalisation or death, in patients with atrial fibrillation or flutter, 29% of whom had a history of heart failure, compared with placebo. The URGENT study demonstrated that treatment of acute heart failure with standard therapy, including intravenous diuretics and nitrates, leads to a rapid resolution of breathlessness in the sitting position but that orthopnoea often persists. The INH study showed that a disease management programme could reduce mortality compared to usual care but not hospitalisation rates. The HEART study failed to recruit its planned number of patients, although it is the largest randomised trial of revascularisation in heart failure reported to date. At a median follow-up of 5 years no difference in mortality was observed but the study lacked power to provide a conclusive result. The selective myosin activator CK-1827452 produced a concentration dependent increase in systolic ejection time, stroke volume and fractional shortening in patients with heart failure compared to placebo.
- Subjects :
- Amiodarone analogs & derivatives
Amiodarone therapeutic use
Anti-Arrhythmia Agents therapeutic use
Atrial Fibrillation drug therapy
Atrial Flutter drug therapy
Cardiotonic Agents therapeutic use
Dronedarone
Heart Failure physiopathology
Heart Failure prevention & control
Humans
Clinical Trials as Topic
Heart Failure therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1388-9842
- Volume :
- 10
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- European journal of heart failure
- Publication Type :
- Report
- Accession number :
- 18678526
- Full Text :
- https://doi.org/10.1016/j.ejheart.2008.07.006