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Synthesis and antiviral properties of some polyphenols related to Salvia genus.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Aug 15; Vol. 18 (16), pp. 4736-40. Date of Electronic Publication: 2008 Jun 21. - Publication Year :
- 2008
-
Abstract
- An efficient synthesis of the acid part of salvianolic acid E 2 is described. Compound 2 was obtained from vanillin in 10 steps and 21% overall yield. During the synthesis of 2 an unexpected 5-oxo-4b,9b-dihydroindano[1,2-b]benzofuran rac-12 was isolated. Both compounds together with the acid part of salvianolic acid D were active as HIV-1 integrase inhibitors at the submicromolar level. But they did not inhibit the replication of the virus on MT-4 cells.
- Subjects :
- Benzaldehydes chemistry
Bromides chemistry
Cell Line
Drug Design
Enzyme Inhibitors pharmacology
HIV Integrase Inhibitors chemical synthesis
HIV Integrase Inhibitors pharmacology
Humans
Inhibitory Concentration 50
Integrase Inhibitors pharmacology
Models, Chemical
Polyphenols
Antiviral Agents chemical synthesis
Antiviral Agents pharmacology
Chemistry, Pharmaceutical methods
Flavonoids chemical synthesis
Flavonoids pharmacology
Phenols chemical synthesis
Phenols pharmacology
Plant Extracts chemical synthesis
Plant Extracts pharmacology
Salvia metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 18
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 18674899
- Full Text :
- https://doi.org/10.1016/j.bmcl.2008.06.063