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Molecular targeted therapies for breast cancer treatment.
- Source :
-
Breast cancer research : BCR [Breast Cancer Res] 2008; Vol. 10 (4), pp. 211. Date of Electronic Publication: 2008 Jul 24. - Publication Year :
- 2008
-
Abstract
- Targeting the oestrogen receptor, HER2 (human epidermal growth factor receptor 2) and vascular endothelial growth factor has markedly improved breast cancer therapy. New targeted therapeutic approaches to induction of apoptosis or inhibition of anti-apoptosis, cell cycle progression, signal transduction and angiogenesis are described. The molecular pathways and their inhibitory or repair mechanisms are discussed in the preclinical and clinical settings.
- Subjects :
- Apoptosis
Breast Neoplasms pathology
Cell Cycle
Cell Line, Tumor
ErbB Receptors metabolism
Female
Humans
Models, Biological
NF-kappa B metabolism
Neovascularization, Pathologic
Proteasome Endopeptidase Complex metabolism
Receptor, ErbB-2 metabolism
Receptors, Estrogen metabolism
Signal Transduction
Ubiquitin metabolism
Breast Neoplasms genetics
Breast Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1465-542X
- Volume :
- 10
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Breast cancer research : BCR
- Publication Type :
- Academic Journal
- Accession number :
- 18671839
- Full Text :
- https://doi.org/10.1186/bcr2112