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Colonic adenoma risk in familial colorectal cancer--a study of six extended kindreds.
- Source :
-
The American journal of gastroenterology [Am J Gastroenterol] 2008 Oct; Vol. 103 (10), pp. 2577-84. Date of Electronic Publication: 2008 Jul 30. - Publication Year :
- 2008
-
Abstract
- Objectives: Most colorectal cancers (CRCs) arise from adenomatous polyps, but the effects of CRC family history on adenoma risk are not well known. This issue is clinically relevant since several medical societies currently recommend earlier and more rigorous colorectal screening for individuals with a strong family history of CRC.<br />Methods: Colonoscopies were performed in 236 first-, second-, and third-degree relatives of 40 index CRC cases from six large kindreds selected from a large population database. The kindreds were selected for significantly greater risk of CRCs compared with the overall population. Known hereditary colon cancer syndromes were clinically and genetically excluded.<br />Results: Thirty-seven percent of relatives were found to have adenomas on colonoscopy. The average age of diagnosis for colon cancer was 63 yr and advanced adenomas 56 yr. Independent predictors of adenomatous polyps in the relatives were advancing age (P < 0.0001), male gender (P < 0.001), and greater degree of relation to CRC cases (P < 0.01). There was no significant predilection of colorectal tumors for the right or left colon. A higher degree of relationship to CRC cases was a significant predictor of having simple and advanced adenomas, but not hyperplastic polyps after adjustment for age and gender.<br />Conclusions: These data support the current recommendations for colonoscopy starting before the age of 50 yr in individuals with a strong family history of CRC.
- Subjects :
- Adenoma epidemiology
Adenoma pathology
Adult
Age Distribution
Aged
Aged, 80 and over
Colonoscopy
Colorectal Neoplasms epidemiology
Colorectal Neoplasms pathology
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prevalence
Retrospective Studies
Risk Factors
Sex Distribution
United States epidemiology
Adenoma genetics
Colorectal Neoplasms genetics
Family
Genetic Predisposition to Disease
Subjects
Details
- Language :
- English
- ISSN :
- 1572-0241
- Volume :
- 103
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The American journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 18671820
- Full Text :
- https://doi.org/10.1111/j.1572-0241.2008.02019.x