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Genetic analysis implicates resistin in HIV lipodystrophy.
- Source :
-
AIDS (London, England) [AIDS] 2008 Aug 20; Vol. 22 (13), pp. 1561-8. - Publication Year :
- 2008
-
Abstract
- Objectives: To investigate the role of genetic variation in influencing the risk of metabolic complications associated with highly active antiretroviral therapy (HAART).<br />Methods: Cluster analysis of metabolic traits of 189 patients enrolled in ACTG5005s, the metabolic substudy of ACTG384, a clinical trial of HAART, was performed to identify a subgroup of individuals with increased risk of developing a cluster of metabolic abnormalities after exposure to HAART. Almost 300 single nucleotide polymorphisms in 135 candidate genes were evaluated for their association with this subgroup.<br />Results: A subgroup of patients was identified that had a normal metabolic profile at baseline but developed significantly elevated lipids and insulin resistance on HAART. This high-risk subgroup of patients also experienced significant body composition changes, particularly limb fat loss. Candidate gene analysis revealed that a single nucleotide polymorphism in resistin, a gene previously implicated in obesity and insulin resistance, was associated with this high-risk group (P = 0.0003).<br />Conclusion: Genetic variation in resistin is associated with metabolic complications caused by HAART.
- Subjects :
- Adult
Anti-Retroviral Agents therapeutic use
Antiretroviral Therapy, Highly Active adverse effects
Blood Glucose analysis
Body Composition drug effects
Cholesterol blood
Cluster Analysis
Genotype
HIV-Associated Lipodystrophy Syndrome drug therapy
HIV-Associated Lipodystrophy Syndrome metabolism
Humans
Insulin Resistance
Male
Middle Aged
Resistin metabolism
Risk Assessment methods
Sequence Analysis
Triglycerides blood
Anti-Retroviral Agents adverse effects
HIV-Associated Lipodystrophy Syndrome genetics
Polymorphism, Single Nucleotide
Resistin genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5571
- Volume :
- 22
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- AIDS (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 18670214
- Full Text :
- https://doi.org/10.1097/QAD.0b013e32830a9886