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Genetic analysis implicates resistin in HIV lipodystrophy.

Authors :
Ranade K
Geese WJ
Noor M
Flint O
Tebas P
Mulligan K
Powderly W
Grinspoon SK
Dube MP
Source :
AIDS (London, England) [AIDS] 2008 Aug 20; Vol. 22 (13), pp. 1561-8.
Publication Year :
2008

Abstract

Objectives: To investigate the role of genetic variation in influencing the risk of metabolic complications associated with highly active antiretroviral therapy (HAART).<br />Methods: Cluster analysis of metabolic traits of 189 patients enrolled in ACTG5005s, the metabolic substudy of ACTG384, a clinical trial of HAART, was performed to identify a subgroup of individuals with increased risk of developing a cluster of metabolic abnormalities after exposure to HAART. Almost 300 single nucleotide polymorphisms in 135 candidate genes were evaluated for their association with this subgroup.<br />Results: A subgroup of patients was identified that had a normal metabolic profile at baseline but developed significantly elevated lipids and insulin resistance on HAART. This high-risk subgroup of patients also experienced significant body composition changes, particularly limb fat loss. Candidate gene analysis revealed that a single nucleotide polymorphism in resistin, a gene previously implicated in obesity and insulin resistance, was associated with this high-risk group (P = 0.0003).<br />Conclusion: Genetic variation in resistin is associated with metabolic complications caused by HAART.

Details

Language :
English
ISSN :
1473-5571
Volume :
22
Issue :
13
Database :
MEDLINE
Journal :
AIDS (London, England)
Publication Type :
Academic Journal
Accession number :
18670214
Full Text :
https://doi.org/10.1097/QAD.0b013e32830a9886