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Tamoxifen's protection against breast cancer recurrence is not reduced by concurrent use of the SSRI citalopram.
- Source :
-
British journal of cancer [Br J Cancer] 2008 Aug 19; Vol. 99 (4), pp. 616-21. Date of Electronic Publication: 2008 Jul 29. - Publication Year :
- 2008
-
Abstract
- Tamoxifen remains an important adjuvant therapy to reduce the rate of breast cancer recurrence among patients with oestrogen-receptor-positive tumours. Cytochrome P-450 2D6 metabolizes tamoxifen to metabolites that more readily bind the oestrogen receptor. This enzyme also metabolizes selective serotonin reuptake inhibitors (SSRI), so these widely used drugs - when taken concurrently - may reduce tamoxifen's prevention of breast cancer recurrence. We studied citalopram use in 184 cases of breast cancer recurrence and 184 matched controls without recurrence after equivalent follow-up. Cases and controls were nested in a population of female residents of Northern Denmark with stages I-III oestrogen-receptor-positive breast cancer 1985-2001 and who took tamoxifen for 1, 2, or most often for 5 years. We ascertained prescription histories by linking participants' central personal registry numbers to prescription databases from the National Health Service. Seventeen cases (9%) and 21 controls (11%) received at least one prescription for the SSRI citalopram while taking tamoxifen (adjusted conditional odds ratio=0.85, 95% confidence interval=0.42, 1.7). We also observed no reduction of tamoxifen effectiveness among regular citalopram users (>or=30% overlap with tamoxifen use). These results suggest that concurrent use of citalopram does not reduce tamoxifen's prevention of breast cancer recurrence.
- Subjects :
- Adult
Aged
Breast Neoplasms radiotherapy
Breast Neoplasms surgery
Case-Control Studies
Drug Therapy, Combination
Female
Humans
Middle Aged
Neoplasm Recurrence, Local diagnosis
Neoplasm Staging
Survival Rate
Treatment Outcome
Antineoplastic Agents, Hormonal therapeutic use
Breast Neoplasms drug therapy
Citalopram therapeutic use
Neoplasm Recurrence, Local prevention & control
Selective Serotonin Reuptake Inhibitors therapeutic use
Tamoxifen therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1532-1827
- Volume :
- 99
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- British journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 18665165
- Full Text :
- https://doi.org/10.1038/sj.bjc.6604533