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Novel mechanisms of protein synthesis in diabetic nephropathy--role of mRNA translation.
- Source :
-
Reviews in endocrine & metabolic disorders [Rev Endocr Metab Disord] 2008 Dec; Vol. 9 (4), pp. 255-66. - Publication Year :
- 2008
-
Abstract
- Ambient protein levels are affected by both synthesis and degradation. Synthesis of a protein is regulated by transcription and messenger RNA (mRNA) translation. Translation has emerged as an important site of regulation of protein expression during development and disease. It is under the control of distinct factors that regulate initiation, elongation and termination phases. Regulation of translation occurs via signaling reactions, guanosine diphosphate-guanosine triphosphate binding and by participation of non-coding RNA species such as microRNA. Recent work has revealed an important role for translation in hypertrophy, matrix protein synthesis, elaboration of growth factors in in vivo and in vitro models of diabetic nephropathy. Studies of translation dysregulation in diabetic nephropathy have enabled identification of novel therapeutic targets. Translation of mRNA is a fertile field for exploration in investigation of kidney disease.
- Subjects :
- AMP-Activated Protein Kinases physiology
Angiotensin II metabolism
Animals
Eukaryotic Initiation Factors physiology
Extracellular Matrix metabolism
Humans
Hypertrophy enzymology
Kidney pathology
MicroRNAs physiology
Models, Biological
Peptide Chain Elongation, Translational
Signal Transduction
Diabetic Nephropathies metabolism
Protein Biosynthesis physiology
RNA, Messenger metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1389-9155
- Volume :
- 9
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Reviews in endocrine & metabolic disorders
- Publication Type :
- Academic Journal
- Accession number :
- 18654857
- Full Text :
- https://doi.org/10.1007/s11154-008-9091-3