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Anti-atherosclerotic activity of triacsin C, an acyl-CoA synthetase inhibitor.
- Source :
-
The Journal of antibiotics [J Antibiot (Tokyo)] 2008 May; Vol. 61 (5), pp. 318-21. - Publication Year :
- 2008
-
Abstract
- As previously reported, triacsin C, a selective inhibitor of acyl-CoA synthetase, inhibited the synthesis of cholesteryl ester and triacylglycerol in mouse peritoneal macrophages, leading to a reduction of lipid droplets. Therefore, the in vivo efficacy was studied. Low-density lipoprotein receptor-knockout (LDLR-/-) mice were fed a high cholesterol diet (0.15%) for two months to measure the atherogenic areas of the hearts and aortas. When triacsin C was orally administered (10 mg/kg/day), the atherosclerotic areas were significantly reduced by 86% in aorta and 36% in hearts. The results strongly suggested that triacsin C shows anti-atherogenic activity by inhibiting acyl-CoA synthetase activity.
- Subjects :
- Animals
Aorta, Thoracic pathology
Atherosclerosis pathology
Blood Glucose metabolism
Body Weight drug effects
Cholesterol blood
Cholesterol, Dietary toxicity
Fatty Acids, Nonesterified blood
Mice
Mice, Knockout
Myocardium pathology
Receptors, LDL genetics
Streptomyces chemistry
Streptomyces metabolism
Triazenes isolation & purification
Triglycerides blood
Atherosclerosis prevention & control
Coenzyme A Ligases antagonists & inhibitors
Enzyme Inhibitors pharmacology
Triazenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0021-8820
- Volume :
- 61
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 18653998
- Full Text :
- https://doi.org/10.1038/ja.2008.45