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Increased levels of activated T-cells and reduced levels of CD4/CD25+ cells in peripheral blood of Guillain-Barré syndrome patients compared to controls.
- Source :
-
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2008 Sep; Vol. 15 (9), pp. 1031-5. Date of Electronic Publication: 2008 Jul 23. - Publication Year :
- 2008
-
Abstract
- Guillain-Barré syndrome (GBS) is a severe, self-limiting, autoimmune motor neuropathy. This study was performed to investigate the numbers of activated T-cells and regulatory T-cells, and CD95 and bcl-2 expression in GBS patients compared to controls. The percentage of cells expressing CD69 (activated T-cells) was increased in the blood of both patients with GBS and those with other neuropathies compared to healthy controls. GBS patients displayed significant decreases in the percentage of T-lymphocytes (CD3) and CD4/CD25+ cells (T regulatory cells) compared to patients with other neuropathies and a reduction in the percentage of cytotoxic/suppressor T-lymphocytes (CD8) compared to healthy controls. CD95 expression was reduced in GBS compared to patients with other neuropathies and expression of Bcl-2 was increased in GBS compared to healthy controls. We therefore suggest that in GBS there are increased activated T-cells and disturbances in regulatory T-cells and T-cell apoptosis.
- Subjects :
- Antigens, CD blood
Antigens, CD immunology
Antigens, Differentiation, T-Lymphocyte blood
Antigens, Differentiation, T-Lymphocyte immunology
Apoptosis immunology
Biomarkers blood
Guillain-Barre Syndrome blood
Humans
Lectins, C-Type
Peripheral Nerves immunology
Peripheral Nerves physiopathology
Proto-Oncogene Proteins c-bcl-2 blood
Proto-Oncogene Proteins c-bcl-2 metabolism
T-Lymphocytes, Regulatory immunology
Up-Regulation immunology
fas Receptor blood
fas Receptor metabolism
CD4 Antigens metabolism
CD4-Positive T-Lymphocytes immunology
Guillain-Barre Syndrome immunology
Interleukin-2 Receptor alpha Subunit metabolism
Lymphocyte Activation immunology
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0967-5868
- Volume :
- 15
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
- Publication Type :
- Academic Journal
- Accession number :
- 18653346
- Full Text :
- https://doi.org/10.1016/j.jocn.2007.09.016