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Synthesis and biological evaluation of C-12' substituted vinflunine derivatives.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Aug 15; Vol. 18 (16), pp. 4602-5. Date of Electronic Publication: 2008 Jul 12. - Publication Year :
- 2008
-
Abstract
- A series of novel C-12' substituted vinflunine derivatives have been synthesized. Several compounds in this series possess comparable in vitro cytotoxic potency against A549 cell lines.
- Subjects :
- Antineoplastic Agents, Phytogenic chemistry
Cell Line, Tumor
Drug Design
Humans
Inhibitory Concentration 50
Microtubules chemistry
Models, Chemical
Molecular Conformation
Sodium Azide pharmacology
Tubulin chemistry
Vinblastine chemical synthesis
Vinblastine chemistry
Vinblastine pharmacology
Antineoplastic Agents, Phytogenic chemical synthesis
Antineoplastic Agents, Phytogenic pharmacology
Chemistry, Pharmaceutical methods
Drug Screening Assays, Antitumor
Vinblastine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 18
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 18653334
- Full Text :
- https://doi.org/10.1016/j.bmcl.2008.07.025