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Renal transplantation is not associated with regression of left ventricular hypertrophy: a magnetic resonance study.
- Source :
-
Clinical journal of the American Society of Nephrology : CJASN [Clin J Am Soc Nephrol] 2008 Nov; Vol. 3 (6), pp. 1807-11. Date of Electronic Publication: 2008 Jul 23. - Publication Year :
- 2008
-
Abstract
- Background and Objectives: Patients with end-stage renal failure (ESRD) have an increased risk of premature cardiovascular (CV) disease. Left ventricular hypertrophy is an independent risk factor for CV events and death in ESRD. Renal transplantation has been associated with reduction in CV risk and echocardiographic regression of left ventricular hypertrophy. However, echocardiography overestimates LV mass in ESRD patients. Cardiac magnetic resonance (CMR) provides more detailed, volume-independent, measures of cardiac structure. Changes in LV mass measured by CMR after renal transplantation were studied.<br />Design, Setting, Participants, & Measurements: Fifty patients underwent CMR on two occasions. Twenty-five were transplanted before the second scan. CMR was performed to measure LV mass index (LVMI), ejection fraction, end-diastolic and end-systolic volumes. Changes were expressed as percentage change over time. Patients with CV events between scans (e.g., acute coronary syndrome, myocardial infarction) were excluded. All transplant patients had serum creatinine <150 mumol/L.<br />Results: There was no significant change in LVMI between patients who underwent renal transplantation and those who remained on dialysis (transplanted mean, 2.75%/yr, +/- 9.1 versus dialysis, -3.6%/yr +/- 16.7). In addition, there were no significant changes in end-diastolic volume (transplant, 0.1%/yr +/- 19.5 versus not transplanted, -3.4%/yr +/- 31.5), end-systolic volume (transplanted mean, 15.2%/yr +/- 65.2 versus not transplanted, 3.0%/yr +/- 55.5), or ejection fraction (transplant, 2.1%/yr +/- 11.9 versus not transplanted, -0.4%/yr +/- 5.3).<br />Conclusions: Renal transplantation is not associated with significant regression of LVMI on CMR compared with patients who remain on the transplant waiting list.
- Subjects :
- Adult
Female
Humans
Hypertrophy, Left Ventricular etiology
Hypertrophy, Left Ventricular physiopathology
Kidney Failure, Chronic complications
Kidney Failure, Chronic pathology
Kidney Failure, Chronic physiopathology
Male
Middle Aged
Stroke Volume
Time Factors
Treatment Outcome
Ventricular Function, Left
Waiting Lists
Hypertrophy, Left Ventricular pathology
Kidney Failure, Chronic surgery
Kidney Transplantation
Magnetic Resonance Imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1555-905X
- Volume :
- 3
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Clinical journal of the American Society of Nephrology : CJASN
- Publication Type :
- Academic Journal
- Accession number :
- 18650407
- Full Text :
- https://doi.org/10.2215/CJN.01400308