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Effects of dehydroepiandrosterone sulfate and progesterone on spatial learning and memory in young and aged mice.
- Source :
-
The Journal of general psychology [J Gen Psychol] 2008 Jul; Vol. 135 (3), pp. 271-86. - Publication Year :
- 2008
-
Abstract
- Young (2-4 months) and aged (14-16 months) male Swiss-Webster albino mice (n = 7 per group) were subcutaneously injected with 20 mg/kg/day dehydroepiandrosterone sulfate (DHEAS), progesterone (P), DHEAS + P, or vehicle control and trained over a 5-day period in a Morris water maze. The subjects were tested 48 hr after training for memory recall as measured by latencies to locate the hidden platform, and trunk blood was collected immediately thereafter. As expected, latency to platform decreased for all groups over the 6 testing days, with aged mice taking longer to reach platform than did young mice. However, results did not support the hypotheses that DHEAS-treated mice would exhibit shorter latencies and that P-treated mice would show longer latencies to platform in comparison with age-matched controls. These results raise doubts about the effectiveness of commercially available supplements claiming to promote enhanced memory in humans.
- Subjects :
- Animals
Drug Interactions
Male
Mice
Reaction Time drug effects
Retention, Psychology drug effects
Aging drug effects
Dehydroepiandrosterone Sulfate pharmacology
Escape Reaction drug effects
Maze Learning drug effects
Mental Recall drug effects
Orientation drug effects
Progesterone pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1309
- Volume :
- 135
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of general psychology
- Publication Type :
- Academic Journal
- Accession number :
- 18649493
- Full Text :
- https://doi.org/10.3200/GENP.135.3.271-286