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The study of improved controlled release of vincristine sulfate from collagen-chitosan complex film.
- Source :
-
Artificial cells, blood substitutes, and immobilization biotechnology [Artif Cells Blood Substit Immobil Biotechnol] 2008; Vol. 36 (4), pp. 372-85. - Publication Year :
- 2008
-
Abstract
- A water-in-oil-in-oil double-emulsion solvent/evaporation method was used to prepare vincristine sulfate (VCR) loaded poly(lactide-co-glycolide) microspheres, and then VCR microspheres were mixed with collagen and (or) chitosan swelling solution and lyophilized to form polymeric films. The films were cross-linked by 0.3% glutaraldehyde (GA). Encapsulation efficiency and release kinetics of VCR microspheres were determined, as well as release kinetics and in vitro degradation of the film. The rate of VCR release from the film submerged in PBS (pH 6.8) and the content were measured by high-performance liquid chromatography (HPLC). The physichemical properties of the film, such as surface morphology, mechanical function, and differential scanning calorimetry, were also measured. VCR was released from the film in a prolonged period and the initial burst release of the film was less significant. In the degradation experiment, the film containing chitosan degraded more slowly than that without chitosan. The films comprising collagen and chitosan could achieve the release kinectics of a relatively constant release. It has a promising future.
- Subjects :
- Absorbable Implants
Analysis of Variance
Antineoplastic Agents, Phytogenic administration & dosage
Antineoplastic Agents, Phytogenic chemistry
Antineoplastic Agents, Phytogenic pharmacokinetics
Calorimetry, Differential Scanning
Collagen metabolism
Collagenases metabolism
Drug Implants pharmacokinetics
Emulsions
Lactic Acid chemistry
Microscopy, Electron, Scanning
Microspheres
Polyglycolic Acid chemistry
Polylactic Acid-Polyglycolic Acid Copolymer
Porosity
Surface Properties
Tensile Strength
Time Factors
Vincristine administration & dosage
Vincristine pharmacokinetics
Chitosan chemistry
Collagen chemistry
Drug Implants chemical synthesis
Vincristine chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1532-4184
- Volume :
- 36
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Artificial cells, blood substitutes, and immobilization biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 18649172
- Full Text :
- https://doi.org/10.1080/10731190802239057