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NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B.
- Source :
-
Nature structural & molecular biology [Nat Struct Mol Biol] 2008 Aug; Vol. 15 (8), pp. 868-9. Date of Electronic Publication: 2008 Jul 20. - Publication Year :
- 2008
-
Abstract
- The NMR structure of budding yeast chaperone Chz1 complexed with histones H2A.Z-H2B has been determined. Chz1 forms a long irregular chain capped by two short alpha-helices, and uses both positively and negatively charged residues to stabilize the histone dimer. A molecular model that docks Chz1 onto the nucleosome has implications for its potential functions.
- Subjects :
- Arginine chemistry
Carbon chemistry
Dimerization
Histone Chaperones
Lysine chemistry
Molecular Conformation
Nitrogen chemistry
Nucleosomes chemistry
Protein Conformation
Protein Structure, Secondary
Saccharomyces cerevisiae metabolism
Static Electricity
Histones chemistry
Magnetic Resonance Spectroscopy methods
Molecular Chaperones chemistry
Saccharomyces cerevisiae Proteins chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1545-9985
- Volume :
- 15
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Nature structural & molecular biology
- Publication Type :
- Academic Journal
- Accession number :
- 18641662
- Full Text :
- https://doi.org/10.1038/nsmb.1465