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Pulmonary histopathology in an experimental model of chronic aspiration is independent of acidity.
- Source :
-
Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med (Maywood)] 2008 Oct; Vol. 233 (10), pp. 1202-12. Date of Electronic Publication: 2008 Jul 18. - Publication Year :
- 2008
-
Abstract
- Gastroesophageal reflux has become a major health concern in industrialized countries, with drugs aimed at blocking acid production being more frequently prescribed than any other drug. Damage to lung tissue as a result of chronic aspiration of gastric fluid is a primary health risk associated with gastro-esophageal reflux, with such aspiration being suspected in the induction or exacerbation of asthma and other lung diseases. In this study, a rodent model of chronic aspiration was used to characterize the pulmonary histopathology produced by repetitive aspiration events and to investigate the pathologic roles of individual gastric fluid components such as acid and particulate food matter. Rats exposed to chronic aspiration of whole gastric fluid developed a pathology distinct from that of acute lung injury, characterized by granulomatous interstitial pneumonitis with prominent formation of multinucleated giant cells. This pattern of injury could be reproduced with chronic aspiration of particulate food matter and with chronic aspiration of pH-neutralized gastric fluid, but not with chronic aspiration of hydrochloric acid. Thus, since acid-neutralizing therapy is currently the mainstay of treatment for patients with reflux-associated respiratory symptoms, these results strongly suggest that alternative therapeutic approaches aimed at preventing chronic-aspiration induced lung injury may be warranted.
- Subjects :
- Animals
Bronchoalveolar Lavage Fluid chemistry
Chronic Disease
Cytokines analysis
Disease Models, Animal
Gastric Juice physiology
Gastroesophageal Reflux complications
Gastrointestinal Contents
Hydrogen-Ion Concentration
Male
Pneumonia, Aspiration etiology
Pneumonia, Aspiration physiopathology
Rats
Rats, Inbred F344
Respiratory Aspiration complications
Respiratory Aspiration physiopathology
Gastric Acid physiology
Lung pathology
Pneumonia, Aspiration pathology
Respiratory Aspiration pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1535-3702
- Volume :
- 233
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Experimental biology and medicine (Maywood, N.J.)
- Publication Type :
- Academic Journal
- Accession number :
- 18641054
- Full Text :
- https://doi.org/10.3181/0801-RM-17