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T and B cell human responses to European bat lyssavirus after post-exposure rabies vaccination.
- Source :
-
Clinical and experimental immunology [Clin Exp Immunol] 1991 Aug; Vol. 85 (2), pp. 224-30. - Publication Year :
- 1991
-
Abstract
- T and B cell human responses to European bat lyssavirus (EBL1) induced by post-exposure rabies vaccination (PM virus vaccine) were evaluated by measuring plasmatic titres of EBL1-specific neutralizing antibodies; specific EBL1-binding antibodies; and proliferation indices of peripheral blood lymphocytes stimulated in vitro with EBL1. These parameters for vaccination efficacy were compared with those obtained with vaccine-related viruses (CVS and ERA) and with a non-vaccine-related virus. Mokola virus, the last implicated in vaccination failures. Twenty-two patients exposed to rabies risk who received a reduced rabies post-exposure vaccination were involved in the study. On day 21, vaccine induced CVS-specific neutralizing antibodies in all patients; but EBL1-specific neutralizing antibodies were induced in only 73% of patients. No vaccine had Mokola-specific neutralizing antibodies. Patients having EBL1-specific neutralizing antibodies were usually those in whom vaccination induced high titres of CVS-specific neutralizing antibodies. On day 21, peripheral blood lymphocytes of 86% of patients could be restimulated in vitro with vaccine, 43% with EBL1 and 45% with Mokola. Patients exhibiting a high vaccine-specific proliferation response more likely developed an EBL1- or a Mokola-specific proliferative response. No correlation was found between T and B cell responses. Rabies vaccination induced neither T nor B cell EBL1-specific responses in 22% of patients.
- Subjects :
- Adult
Animals
Antibodies, Viral immunology
Antibody Specificity
Chiroptera microbiology
Female
Humans
Lymphocyte Activation
Male
Middle Aged
Neutralization Tests
Species Specificity
B-Lymphocytes immunology
Rabies Vaccines administration & dosage
Rhabdoviridae immunology
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0009-9104
- Volume :
- 85
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical and experimental immunology
- Publication Type :
- Academic Journal
- Accession number :
- 1864001
- Full Text :
- https://doi.org/10.1111/j.1365-2249.1991.tb05709.x