Back to Search
Start Over
Assessment of biomarkers in asbestos-exposed workers as indicators of cancer risk.
- Source :
-
Mutation research [Mutat Res] 2008 Aug-Sep; Vol. 655 (1-2), pp. 52-8. - Publication Year :
- 2008
-
Abstract
- Epidemiological studies have shown that mortality from malignant mesothelioma (MM) and lung cancer have increased with increasing cumulative exposure to asbestos. To investigate whether tumour-related biomarkers can contribute towards the evaluation of the carcinogenic risk in populations exposed to asbestos, the DNA adduct 8-hydroxy-2'-deoxyguanosine (80HdG), interleukine-6 (IL-6), platelet-derived growth factor (PDGF-BB), hepatocyte growth factor (HGF), basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGFbeta) and soluble mesothelin-related peptides (SMRPs) were analysed in a cohort of workers differently exposed to asbestos fibres at the workplace. To document biomarker levels in an unexposed population, 54 age-matched subjects were enrolled. A total of 119 subjects with a history of occupational exposure to asbestos underwent clinical examination and were interviewed by trained personnel, responding to a detailed questionnaire related to duration of asbestos exposure, smoking, and occupational task. According to the occupational tasks, asbestos-exposed subjects were analysed for their asbestos cumulative dose and the association with the biomarkers was evaluated. Among the occupational groups, maintenance workers, pipe fitters and electricians were exposed to a higher cumulative dose of asbestos fibres. Exposure to asbestos significantly increased the steady-state content of 80HdG in DNA. Elevated levels of 80HdG and IL-6 best reflected a high level of SMRPs, which is related to cell transformation. Subjects heavily exposed to asbestos [> 60(ff/cm3) x years] showed also a higher level of angiogenic factors. A combination of angiogenic biomarkers with a specific mesothelioma-biomarker such as SMRPs could be used for close surveillance of workers with a history of asbestos exposure.
- Subjects :
- Aged
Biomarkers, Tumor analysis
Female
Humans
Lymphocytes metabolism
Male
Mesothelioma diagnosis
Mesothelioma prevention & control
Middle Aged
Occupational Diseases diagnosis
Occupational Diseases prevention & control
Pleural Neoplasms diagnosis
Pleural Neoplasms prevention & control
Regression Analysis
Risk Factors
Asbestos adverse effects
Biomarkers, Tumor blood
Mesothelioma blood
Occupational Diseases blood
Occupational Exposure
Pleural Neoplasms blood
Subjects
Details
- Language :
- English
- ISSN :
- 0027-5107
- Volume :
- 655
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Mutation research
- Publication Type :
- Academic Journal
- Accession number :
- 18638565
- Full Text :
- https://doi.org/10.1016/j.mrgentox.2008.06.011