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Histopathological evolution of a cutaneous myxofibrosarcoma.
- Source :
-
The Australasian journal of dermatology [Australas J Dermatol] 2008 Aug; Vol. 49 (3), pp. 169-72. - Publication Year :
- 2008
-
Abstract
- A 54-year-old woman presented with a 6-month history of a tender and swollen plaque appearing as a panniculitis affecting the left pretibial area. The initial histopathology revealed dermal and subcutaneous inflammation with interstitial histiocytes and mucinosis suggestive of either granuloma annulare or necrobiosis lipoidica. Over the subsequent 6 months the plaque grew progressively, despite treatment with topical corticosteroids under occlusion. Distal to the plaque reduced sensation developed in the limb. Biopsies of the nodular areas now revealed a dense dermal infiltrate of atypical spindle cells within a prominent myxoid stroma and a pleomorphic multinucleated epithelioid cell component. These features were those of an intermediate grade myxofibrosarcoma. This soft-tissue sarcoma may initially masquerade clinically as a panniculitis and a granulomatous process on biopsy as in our patient, leading to a delay in surgical therapy.
Details
- Language :
- English
- ISSN :
- 1440-0960
- Volume :
- 49
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Australasian journal of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 18638228
- Full Text :
- https://doi.org/10.1111/j.1440-0960.2008.00461.x