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The presence of TP53 mutation at diagnosis of follicular lymphoma identifies a high-risk group of patients with shortened time to disease progression and poorer overall survival.

Authors :
O'Shea D
O'Riain C
Taylor C
Waters R
Carlotti E
Macdougall F
Gribben J
Rosenwald A
Ott G
Rimsza LM
Smeland EB
Johnson N
Campo E
Greiner TC
Chan WC
Gascoyne RD
Wright G
Staudt LM
Lister TA
Fitzgibbon J
Source :
Blood [Blood] 2008 Oct 15; Vol. 112 (8), pp. 3126-9. Date of Electronic Publication: 2008 Jul 15.
Publication Year :
2008

Abstract

The International Prognostic Index and the Follicular Lymphoma International Prognostic Index are widely used for the risk assessment of follicular lymphoma (FL). Although molecular studies have provided insight into the biology of FL, no molecular marker has impacted on treatment stratification. Because TP53 mutations are associated with poor prognosis in hematologic malignancies, we investigated the prognostic value of TP53 mutation at diagnosis in FL. Heterozygous TP53 mutation was detected in 12 of 185 (6%) analyzed cases. Mutation was associated with older age (P = .02) and higher International Prognostic Index score (P = .04). On multivariate analysis, TP53 mutation correlated with shorter progression-free survival (P < .001) and overall survival (P = .009). TP53 mutation was associated with low expression of the immune-response 1 gene expression signature (P = .016) and with an unfavorable gene expression-based survival predictor score (P < .001), demonstrating for the first time that molecular features of the malignant cell may correlate with the nature of the immune response in FL.

Details

Language :
English
ISSN :
1528-0020
Volume :
112
Issue :
8
Database :
MEDLINE
Journal :
Blood
Publication Type :
Academic Journal
Accession number :
18628487
Full Text :
https://doi.org/10.1182/blood-2008-05-154013