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Bilateral retiform Sertoli-Leydig cell tumour in a bitch. Alpha-inhibin and epithelial membrane antigen as useful tools for differential diagnosis.
- Source :
-
Journal of comparative pathology [J Comp Pathol] 2008 Aug-Oct; Vol. 139 (2-3), pp. 137-40. Date of Electronic Publication: 2008 Jul 11. - Publication Year :
- 2008
-
Abstract
- Sertoli-Leydig cell tumours with a retiform pattern similar to the pattern of the rete testis are a subtype of sex cord-stromal tumours recognized in the human WHO histological classification of ovarian tumours but not in the equivalent classification for domestic animals. The morphology of the tumour may be confused with that of the more common ovarian epithelial tumours. The gross, microscopical and immunohistochemical features of a canine retiform Sertoli-Leydig cell tumour and its comparison with the human counterpart are presented in this report. Both ovaries were enlarged and cystic. Microscopically, the tumour was cystic with tubulopapillary growth characterized by narrow, elongated branching tubules. Immunohistochemically, the tumour cells expressed alpha-inhibin, while epithelial membrane antigen was not detected, indicating a sex cord-stromal origin of the tumour. Additionally, the tumour cells expressed cytokeratin and vimentin in addition to oestrogen receptor alpha and progesterone receptor.
- Subjects :
- Animals
Diagnosis, Differential
Dogs
Female
Immunohistochemistry
Neoplasms, Glandular and Epithelial pathology
Ovarian Neoplasms metabolism
Ovarian Neoplasms pathology
Sertoli-Leydig Cell Tumor metabolism
Sertoli-Leydig Cell Tumor pathology
Dog Diseases metabolism
Dog Diseases pathology
Inhibins biosynthesis
Mucin-1 biosynthesis
Ovarian Neoplasms veterinary
Sertoli-Leydig Cell Tumor veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9975
- Volume :
- 139
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Journal of comparative pathology
- Publication Type :
- Academic Journal
- Accession number :
- 18620701
- Full Text :
- https://doi.org/10.1016/j.jcpa.2008.05.006