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Successful kinase bypass with new acyclovir phosphoramidate prodrugs.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Aug 01; Vol. 18 (15), pp. 4364-7. Date of Electronic Publication: 2008 Jun 24. - Publication Year :
- 2008
-
Abstract
- Novel phosphoramidates of acyclovir have been prepared and evaluated in vitro against acyclovir-sensitive and -resistant herpes simplex virus (HSV) types 1 and 2 and varicella-zoster virus (VZV). Unlike the parent nucleoside these novel phosphate prodrugs retain antiviral potency versus the ACV-resistant virus strain, suggesting an efficient bypass of the viral thymidine kinase.
- Subjects :
- Herpesvirus 1, Human drug effects
Herpesvirus 2, Human drug effects
Herpesvirus 3, Human
Humans
Molecular Structure
Acyclovir analogs & derivatives
Acyclovir chemical synthesis
Acyclovir chemistry
Acyclovir pharmacology
Acyclovir therapeutic use
Amides chemical synthesis
Amides chemistry
Amides pharmacology
Amides therapeutic use
Antiviral Agents chemical synthesis
Antiviral Agents chemistry
Antiviral Agents pharmacology
Antiviral Agents therapeutic use
Phosphoric Acids chemical synthesis
Phosphoric Acids chemistry
Phosphoric Acids pharmacology
Phosphoric Acids therapeutic use
Prodrugs chemical synthesis
Prodrugs chemistry
Prodrugs pharmacology
Thymidine Kinase metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 18
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 18614365
- Full Text :
- https://doi.org/10.1016/j.bmcl.2008.06.069