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Comparative analysis of alpha-blocker utilization in combination with 5-alpha reductase inhibitors for enlarged prostate in a managed care setting among Medicare-aged men.
- Source :
-
The American journal of managed care [Am J Manag Care] 2008 May; Vol. 14 (5 Suppl 2), pp. S160-6. - Publication Year :
- 2008
-
Abstract
- Objective: To evaluate the likelihood of alpha-adrenergic antagonist (alpha-blocker) discontinuation in combination with dutasteride or finasteride among patients aged > or =65 years with enlarged prostate.<br />Method: This retrospective analysis used 2003-2006 data representing more than 30 million managed care members. Medical/pharmacy claims were used to select patients, matched 1:1 using propensity scoring. The proportion remaining on alpha-blocker therapy more than 12 months and time to discontinuation were compared between groups, controlling for covariates using survival analysis.<br />Results: The matched sample included 1674 patients. Alpha-blocker therapy discontinuation was observed at 90 days (86.9% dutasteride patients and 91.8% finasteride patients remained on alpha-blocker therapy). After 12 months, more dutasteride patients discontinued (38.1% remained) alpha-blocker therapy than finasteride patients (56.3% remained).<br />Conclusions: Patients discontinued alpha-blocker therapy as early as 3 months. Those taking dutasteride were 64% more likely to discontinue alpha-blocker therapy than patients taking finasteride. Dutasteride's impact on discontinuation may have important implications and should be examined further.
- Subjects :
- Aged
Aged, 80 and over
Drug Therapy, Combination
Dutasteride
Humans
Male
Managed Care Programs
Medicare
Prostatic Hyperplasia enzymology
Retrospective Studies
Treatment Outcome
United States
5-alpha Reductase Inhibitors
Adrenergic alpha-Antagonists therapeutic use
Azasteroids therapeutic use
Enzyme Inhibitors therapeutic use
Finasteride therapeutic use
Prostatic Hyperplasia drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1936-2692
- Volume :
- 14
- Issue :
- 5 Suppl 2
- Database :
- MEDLINE
- Journal :
- The American journal of managed care
- Publication Type :
- Academic Journal
- Accession number :
- 18611090