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Plasmodium yoelii: novel rhoptry proteins identified within the body of merozoite rhoptries in rodent Plasmodium malaria.
- Source :
-
Experimental parasitology [Exp Parasitol] 2008 Sep; Vol. 120 (1), pp. 113-7. Date of Electronic Publication: 2008 May 27. - Publication Year :
- 2008
-
Abstract
- The biogenesis, organization and function of the rhoptries are not well understood. Antisera were prepared to synthetic peptides prepared as multiple antigenic peptides (MAPs) obtained from a Plasmodium yoelii merozoite rhoptry proteome analysis. The antisera were used in immunofluorescence and immunoelectron microscopy of schizont-infected erythrocytes. Twenty-seven novel rhoptry proteins representing proteases, metabolic enzymes, secreted proteins and hypothetical proteins, were identified in the body of the rhoptries by immunoelectron microscopy. The merozoite rhoptries contain a heterogeneous mixture of proteins that may initiate host cell invasion and establish intracellular parasite development.
- Subjects :
- Animals
Female
Fluorescent Antibody Technique, Indirect
Male
Merozoites chemistry
Merozoites ultrastructure
Mice
Microscopy, Immunoelectron
Organelles chemistry
Organelles ultrastructure
Plasmodium yoelii genetics
Plasmodium yoelii immunology
Plasmodium yoelii ultrastructure
Protozoan Proteins chemistry
Protozoan Proteins immunology
Rabbits
Malaria parasitology
Plasmodium yoelii chemistry
Protozoan Proteins analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2449
- Volume :
- 120
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Experimental parasitology
- Publication Type :
- Academic Journal
- Accession number :
- 18606406
- Full Text :
- https://doi.org/10.1016/j.exppara.2008.05.001