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[Metabonomic study of blood plasma in the assessment of liver graft function].
- Source :
-
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae [Zhongguo Yi Xue Ke Xue Yuan Xue Bao] 2007 Dec; Vol. 29 (6), pp. 725-9. - Publication Year :
- 2007
-
Abstract
- Objective: To access the capability of 1H nuclear magnetic resonance (NMR) -based metabonomics in the evaluation of graft function in the perioperation period of liver transplantation.<br />Methods: Plasma samples of 15 male primary hepatic carcinoma patients were collected for clinical biochemical analysis and 1H NMR spectroscopy 1 day before operation, 1 day and 1 week after the operation. The NMR data were analyzed using principal component analysis.<br />Results: Metabonomic analysis indicated that, compared with those before operation, blood concentrations of valine, alanine, acetone, succinic acid, glutamine, choline, lactate, and glucose increased significantly 1 day after transplantation. One week later, the levels of lipids and choline increased notably, while those of glucose and amino acids decreased. Principal component analysis showed significant difference between metabolic profiles of plasma samples of variant periods of liver transplantation, due to the variation of the levels of glucose, lipids, lactate, and choline. A good agreement was observed between clinical chemistry and metabonomic data.<br />Conclusions: Metabonomic analysis can clearly identify the difference between the plasma samples of primary hepatic carcinoma patients at different time during the perioperation period of liver transplantation. It therefore may be a promising new technology in predicting the outcomes of liver transplantation.
- Subjects :
- Acetone blood
Acetone chemistry
Alanine blood
Alanine chemistry
Biomarkers chemistry
Blood Glucose chemistry
Blood Glucose metabolism
Carcinoma chemistry
Carcinoma surgery
Choline blood
Choline chemistry
Glutamine blood
Glutamine chemistry
Humans
Lactic Acid blood
Lactic Acid chemistry
Liver metabolism
Liver Neoplasms chemistry
Liver Neoplasms surgery
Magnetic Resonance Spectroscopy
Male
Succinic Acid blood
Succinic Acid chemistry
Treatment Outcome
Valine blood
Valine chemistry
Biomarkers blood
Carcinoma blood
Liver Neoplasms blood
Liver Transplantation physiology
Metabolome
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1000-503X
- Volume :
- 29
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
- Publication Type :
- Academic Journal
- Accession number :
- 18595247