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Pathologic complete response confirmed by surgical resection for liver metastases of gastrointestinal stromal tumor after treatment with imatinib mesylate.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2008 Jun 21; Vol. 14 (23), pp. 3763-7. - Publication Year :
- 2008
-
Abstract
- A 39-year-old male underwent distal gastrectomy for a high grade gastrointestinal stromal tumor (GIST). Computed tomography (CT) and magnetic resonance imaging (MRI) 107 mo after the operation, revealed a cystic mass (14 cm in diameter) and a solid mass (9 cm in diameter) in the right and left lobes of the liver, respectively. A biopsy specimen of the solid mass showed a liver metastasis of GIST. The patient received imatinib mesylate (IM) treatment, 400 mg/day orally. Following the IM treatment for a period of 35 mo, the patient underwent partial hepatectomy (S4 + S5). The effect of IM on the metastatic lesions was interpreted as pathologic complete response (CR). Pathologically verified cases showing therapeutic efficacy of IM have been rarely reported.
- Subjects :
- Administration, Oral
Adult
Antineoplastic Agents administration & dosage
Benzamides
Chemotherapy, Adjuvant
Gastrectomy
Gastrointestinal Stromal Tumors surgery
Humans
Imatinib Mesylate
Liver Neoplasms secondary
Magnetic Resonance Imaging
Male
Neoadjuvant Therapy
Piperazines administration & dosage
Protein Kinase Inhibitors administration & dosage
Pyrimidines administration & dosage
Tomography, X-Ray Computed
Treatment Outcome
Antineoplastic Agents therapeutic use
Gastrointestinal Stromal Tumors pathology
Hepatectomy
Liver Neoplasms drug therapy
Liver Neoplasms surgery
Piperazines therapeutic use
Protein Kinase Inhibitors therapeutic use
Pyrimidines therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1007-9327
- Volume :
- 14
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 18595147
- Full Text :
- https://doi.org/10.3748/wjg.14.3763