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Which physical and structural factors of liposome carriers control their drug-loading efficiency?
- Source :
-
Chemistry and physics of lipids [Chem Phys Lipids] 2008 Sep; Vol. 155 (1), pp. 7-15. Date of Electronic Publication: 2008 Jun 11. - Publication Year :
- 2008
-
Abstract
- The correlation between structural and physical properties of lipid membrane and its drug-loading efficiency were studied. The properties of bilayer were altered by incorporation of several lipidic modifiers: cholesterol, oleic acid, methyl oleate, and pegylated lipid. By using the molecular probe technique it was demonstrated that the membrane properties, such as micropolarity, microviscosity and free volume were considerably changed by incorporation of the modifiers. The partitioning of two different porphyrins between the bulk aqueous phase and the modified liposomes was studied using the fluorescence methods, and liposome-binding constants were determined. It was found that cholesterol reduced the partitioning of both porphyrins into liposomal bilayer. On the contrary, the incorporation of methyl oleate and pegylated lipid causes a pronounced increase in the value of the binding constants of both porphyrins. It was concluded that the free volume rather than hydrophobicity of bilayer is a governing factor in the solute partitioning into lipid bilayers.
- Subjects :
- Anisotropy
Chemistry, Pharmaceutical methods
Chemistry, Physical methods
Kinetics
Molecular Conformation
Oxazines pharmacology
Porphyrins chemistry
Pyrenes chemistry
Spectrometry, Fluorescence methods
Spectrophotometry, Ultraviolet methods
Ultraviolet Rays
Drug Carriers
Lipid Bilayers chemistry
Lipids chemistry
Liposomes chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0009-3084
- Volume :
- 155
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Chemistry and physics of lipids
- Publication Type :
- Academic Journal
- Accession number :
- 18590712
- Full Text :
- https://doi.org/10.1016/j.chemphyslip.2008.05.174