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Effects of amiodarone on lung tissue mechanics and parenchyma remodeling.
- Source :
-
Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2008 Jul 31; Vol. 162 (2), pp. 126-31. Date of Electronic Publication: 2008 May 17. - Publication Year :
- 2008
-
Abstract
- We studied the results of chronic oral administration of amiodarone on in vitro lung tissue mechanics, light and electron microscopy. Fifteen Wistar male rats were divided into three groups. In control (CTRL) group animals received saline (0.5 mL/day). In amiodarone (AMIO) groups, amiodarone was administered by gavage at a dose of 175 mg/kg 5 days per week for 6 (6AMIO) or 12 weeks (12AMIO). Lung tissue strips were analyzed 24h after the last drug administration. Tissue resistance and elastance were higher in 6AMIO and 12AMIO than in CTRL, while hysteresivity was similar in all groups. Total amount of collagen fibers in lung parenchyma increased progressively with the time course of the lesion. However, at 6 weeks there was an increase in the amount of type III collagen fibers, while in 12AMIO mainly type I collagen fibers were found. In our study amiodarone increased lung tissue impedance that was accompanied by matrix remodeling and lesion of type II pneumocytes.
- Subjects :
- Analysis of Variance
Animals
Collagen Type I drug effects
Collagen Type III drug effects
Dose-Response Relationship, Drug
Drug Administration Schedule
Elasticity drug effects
In Vitro Techniques
Lung ultrastructure
Male
Rats
Rats, Wistar
Statistics, Nonparametric
Time Factors
Amiodarone adverse effects
Anti-Arrhythmia Agents adverse effects
Extracellular Matrix drug effects
Lung drug effects
Respiratory Mechanics drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1569-9048
- Volume :
- 162
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Respiratory physiology & neurobiology
- Publication Type :
- Academic Journal
- Accession number :
- 18586579
- Full Text :
- https://doi.org/10.1016/j.resp.2008.05.004