Back to Search
Start Over
Differential effects of acute progesterone administration on spatial and object memory in middle-aged and aged female C57BL/6 mice.
- Source :
-
Hormones and behavior [Horm Behav] 2008 Aug; Vol. 54 (3), pp. 455-62. Date of Electronic Publication: 2008 May 27. - Publication Year :
- 2008
-
Abstract
- The present study examined the effects of acute progesterone administration on hippocampal-dependent memory consolidation in ovariectomized middle-aged (16 months old) and aged (22 months old) female mice. Spatial memory was tested in a 2-day Morris water-maze task and object memory was tested using an object recognition task with 24- and 48-h delays. Immediately after water-maze training, mice received i.p. injections of vehicle, or 5.0, 10.0, or 20.0 mg/kg of water-soluble progesterone. Twenty-four hours later, retention of the platform location was tested. No overnight forgetting of the platform location was observed in middle-aged vehicle-treated mice. Acute progesterone administration had no effect on spatial memory in middle-aged mice. However, aged vehicle-treated mice demonstrated impaired memory for the platform location on Day 2 relative to Day 1. Twenty mg/kg, but not 5 or 10 mg/kg, progesterone reversed these deficits, suggesting that 20 mg/kg progesterone can improve spatial memory in aged females. In the object recognition task, mice explored two identical objects and then immediately received vehicle or progesterone injections. In middle-aged mice, 10 and 20 mg/kg progesterone enhanced object memory consolidation, relative to chance, after 24-h, but all doses were ineffective after 48-h. In aged mice, 10 mg/kg progesterone enhanced object memory consolidation, relative to chance, after 24 h, whereas both 5 and 10 mg/kg progesterone enhanced memory after 48 h. Together, these results indicate that acute progesterone differentially enhances hippocampal-dependent memory in middle-aged and aged females.
- Subjects :
- Animals
Dose-Response Relationship, Drug
Female
Hippocampus drug effects
Mice
Mice, Inbred C57BL
Retention, Psychology drug effects
Aging drug effects
Exploratory Behavior drug effects
Maze Learning drug effects
Mental Recall drug effects
Orientation drug effects
Pattern Recognition, Visual drug effects
Progesterone pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-6867
- Volume :
- 54
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Hormones and behavior
- Publication Type :
- Academic Journal
- Accession number :
- 18585714
- Full Text :
- https://doi.org/10.1016/j.yhbeh.2008.05.010