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[Hormonal and vitamin regulation of glucose-6-phosphatases activity in the liver].

Authors :
Vinogradov VV
Mandrik KA
OstrovskiÄ­ IuM
Source :
Ukrains'kyi biokhimichnyi zhurnal [Ukr Biokhim Zh] 1976 Jul-Aug; Vol. 48 (4), pp. 421-5.
Publication Year :
1976

Abstract

Glucose-6-phosphatase (G-6-Phase) activity in the rat liver is established to correlate directly with the content of corticosteroids in blood: it lowers with hypocorticoidism (adrenalectomy) and rises with hypercorticoidism (stress). The highest G-6-Phase activity in the liver of the intact animals is observed in autumn, the lowest one in spring, i.e. in the periods when the adrenals function has minimal and maximal values, respectively. Thiamin (0.4 g/kg) is shown to cause a decrease in the G-6-Phase activity in the liver of the intact rats and adrenalectomized or hypophysectomized animals. An assumption is advanced that the found in the experiment a pronounced insulin-like effect of vitamin B with respect to the G-6-Phase activity is connected with an intensified synthesis of the corresponding hormone in the pancreas.

Details

Language :
Russian
ISSN :
0041-610X
Volume :
48
Issue :
4
Database :
MEDLINE
Journal :
Ukrains'kyi biokhimichnyi zhurnal
Publication Type :
Academic Journal
Accession number :
185765