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Apoptosis-inducing galactolipids from a cultured marine diatom, Phaeodactylum tricornutum.
- Source :
-
Journal of natural products [J Nat Prod] 2008 Jul; Vol. 71 (7), pp. 1197-201. Date of Electronic Publication: 2008 Jun 21. - Publication Year :
- 2008
-
Abstract
- Two monogalactosyl diacylglycerols, 1 and 2, were isolated from the marine diatom Phaeodactylum tricornutum, using the patented ApopScreen cell-based screen for apoptosis-inducing, potential anticancer compounds. The molecular structures of the galactolipids were determined using a combination of NMR, mass spectrometry, and chemical degradation. The bioactivities were confirmed using a specific apoptosis induction assay based on genetically engineered mammalian cell lines with differential, defined capacities for apoptosis. The galactolipids induce apoptosis in micromolar concentrations. This is the first report of apoptosis induction by galactolipids.
- Subjects :
- Animals
Antineoplastic Agents chemistry
Cell Line, Tumor
Drug Screening Assays, Antitumor
Galactolipids chemistry
Genetic Engineering
Mammals
Marine Biology
Molecular Structure
Antineoplastic Agents isolation & purification
Antineoplastic Agents pharmacology
Apoptosis drug effects
Diatoms chemistry
Galactolipids isolation & purification
Galactolipids pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 71
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 18570469
- Full Text :
- https://doi.org/10.1021/np800124k