Back to Search
Start Over
Expressions of EphA2 and EphrinA-1 in early squamous cell cervical carcinomas and their relation to prognosis.
- Source :
-
International journal of medical sciences [Int J Med Sci] 2008 Jun 05; Vol. 5 (3), pp. 121-6. Date of Electronic Publication: 2008 Jun 05. - Publication Year :
- 2008
-
Abstract
- By using immunohistochemistry we investigated the expression of EphA2 and EphrinA-1 in 217 early squamous cell cervical carcinomas and examine their prognostic relevance. For EphA2 expression, 21 tumors (10%) showed negative, 108 (50%) weak positive, 69 (32%) moderate positive and 19 (9%) strong positive, whereas for EphrinA-1 expression, 33 tumors (15%) showed negative, 91 (42%) weak positive, 67 (31%) moderate positive and 26 (12%) strong positive. In univariate analysis high expression (strong staining) of EphrinA-1 was associated with poor disease-free (P = 0.033) and disease-specific (P = 0.039) survival. However, in the multivariate analyses neither EphrinA-1 nor EphA2 was significantly associated to survival. The increased levels of EphA2 and EphrinA-1 in a relative high number of early stage squamous cell carcinomas suggested that these two proteins may play an important role in the development of a subset of early cervical cancers. However, EphA2 and EphrinA-1 were not independently associated with clinical outcome.
- Subjects :
- Adult
Carcinoma, Squamous Cell mortality
Disease-Free Survival
Female
Humans
Immunohistochemistry methods
Middle Aged
Models, Biological
Prognosis
Retrospective Studies
Treatment Outcome
Uterine Cervical Neoplasms mortality
Carcinoma, Squamous Cell metabolism
Ephrin-A1 biosynthesis
Ephrin-A2 biosynthesis
Uterine Cervical Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1449-1907
- Volume :
- 5
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 18566674
- Full Text :
- https://doi.org/10.7150/ijms.5.121