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Association between BMI-1 expression, acute graft-versus-host disease, and outcome following allogeneic stem cell transplantation from HLA-identical siblings in chronic myeloid leukemia.
- Source :
-
Blood [Blood] 2008 Sep 01; Vol. 112 (5), pp. 2163-6. Date of Electronic Publication: 2008 Jun 18. - Publication Year :
- 2008
-
Abstract
- Expression of CD7, ELA-2, PR-3, and the polycomb group gene BMI-1 reflects the intrinsic heterogeneity and predicts prognosis of patients with chronic myeloid leukemia (CML) who were not treated with allogeneic stem cell transplantation (allo-SCT). This study investigated whether expression of these genes determined outcome following allo-SCT in a cohort of 84 patients with chronic-phase (CP) CML. We found that patients expressing BMI-1 at a "high" level before allo-SCT had an improved overall survival (P = .005) related to a reduced transplantation-related mortality. In multivariate analysis, when adjusted for the European Group for Blood and Marrow Transplantation (EBMT)-Gratwohl score and other prog-nostic factors, there was an independent association between BMI-1 expression and grades 2 to 4 acute graft-versus-host disease (relative risk [RR] = 2.85; 95% confidence interval [CI], 1.3-6.4; P = .011), suggesting that BMI-1 measured prior to allo-SCT can serve as a biomarker for predicting outcome in patients with CP-CML receiving allo-SCT, and may thus contribute to better therapeutic decisions.
- Subjects :
- Acute Disease
Adolescent
Adult
Child
Child, Preschool
Female
Gene Expression
Graft vs Host Disease immunology
HLA Antigens
Humans
Leukemia, Myeloid, Chronic-Phase genetics
Leukemia, Myeloid, Chronic-Phase immunology
Leukemia, Myeloid, Chronic-Phase therapy
Male
Middle Aged
Polycomb Repressive Complex 1
Prognosis
Siblings
Graft vs Host Disease etiology
Graft vs Host Disease genetics
Nuclear Proteins genetics
Proto-Oncogene Proteins genetics
Repressor Proteins genetics
Stem Cell Transplantation adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1528-0020
- Volume :
- 112
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Blood
- Publication Type :
- Academic Journal
- Accession number :
- 18565849
- Full Text :
- https://doi.org/10.1182/blood-2008-04-148130