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[Multimodal therapy for malignant pleural mesothelioma including extrapleural pneumonectomy].
- Source :
-
Zentralblatt fur Chirurgie [Zentralbl Chir] 2008 Jun; Vol. 133 (3), pp. 231-7. - Publication Year :
- 2008
-
Abstract
- Multimodal therapy including neoadjuvant chemotherapy with subsequent extrapleural pneumonectomy and postoperative radiotherapy has been shown to improve the survival of patients with malignant pleural mesothelioma (MPM) if they are selected carefully. Careful patient selection is required in order to administer aggressive multimodal therapy only to patients who will benefit from such a treatment. To achieve an accurate staging (<or= cT3, < pN2, cM0), mediastinoscopy is recommended in addition to computed tomography of the chest and upper abdomen. Currently, neoadjuvant chemotherapy with pemetrexed and cisplatin followed by extrapleural pneumonectomy and postoperative radiotherapy is claimed to afford the best treatment results. We have treated 17 patients with such a regimen and achieved a 3-year survival rate of 76 % so far. During the follow-up duration of 23 months, 3 patients (18 %) developed distant metastasis and one (6 %) a mediastinal local recurrence. Multimodal therapy of malignant pleural mesothelioma including extrapleural pneumonectomy should only be performed in specialised centres for thoracic surgery where uncomplicated interdisciplinary communication is the rule and which provide the required expertise in patient selection, operative technique and postoperative care.
- Subjects :
- Aged
Chemotherapy, Adjuvant
Combined Modality Therapy
Disease-Free Survival
Female
Humans
Lymphatic Metastasis pathology
Male
Mesothelioma drug therapy
Mesothelioma pathology
Mesothelioma radiotherapy
Middle Aged
Neoplasm Staging
Pleura pathology
Pleural Neoplasms drug therapy
Pleural Neoplasms pathology
Pleural Neoplasms radiotherapy
Prognosis
Radiotherapy, Adjuvant
Tomography, X-Ray Computed
Mesothelioma surgery
Pleura surgery
Pleural Neoplasms surgery
Pneumonectomy methods
Subjects
Details
- Language :
- German
- ISSN :
- 0044-409X
- Volume :
- 133
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Zentralblatt fur Chirurgie
- Publication Type :
- Academic Journal
- Accession number :
- 18563687
- Full Text :
- https://doi.org/10.1055/s-2008-1076790