Back to Search
Start Over
A diacylglycerol lipase-CB2 cannabinoid pathway regulates adult subventricular zone neurogenesis in an age-dependent manner.
- Source :
-
Molecular and cellular neurosciences [Mol Cell Neurosci] 2008 Aug; Vol. 38 (4), pp. 526-36. Date of Electronic Publication: 2008 May 15. - Publication Year :
- 2008
-
Abstract
- The subventricular zone (SVZ) is a major site of neurogenesis in the adult. We now show that ependymal and proliferating cells in the adult mouse SVZ express diacylglycerol lipases (DAGLs), enzymes that synthesise a CB1/CB2 cannabinoid receptor ligand. DAGL and CB2 antagonists inhibit the proliferation of cultured neural stem cells, and the proliferation of progenitor cells in young animals. Furthermore, CB2 agonists stimulate progenitor cell proliferation in vivo, with this effect being more pronounced in older animals. A similar response was seen with a fatty acid amide hydrolase (FAAH) inhibitor that limits degradation of endocannabinoids. The effects on proliferation were mirrored in changes in the number of neuroblasts migrating from the SVZ to the olfactory bulb (OB). In this context, CB2 antagonists reduced the number of newborn neurons appearing in the OB in the young adult animals while CB2 agonists stimulated this in older animals. These data identify CB2 receptor agonists and FAAH inhibitors as agents that can counteract the naturally observed decline in adult neurogenesis that is associated with ageing.
- Subjects :
- Age Factors
Animals
Cell Line
Cells, Cultured
Cerebral Ventricles cytology
Cerebral Ventricles enzymology
Female
Mice
Mice, Inbred C57BL
Mice, Knockout
Neurons cytology
Neurons enzymology
Neurons physiology
Stem Cells cytology
Stem Cells enzymology
Stem Cells physiology
Aging physiology
Cell Differentiation physiology
Cerebral Ventricles growth & development
Lipoprotein Lipase physiology
Receptor, Cannabinoid, CB2 physiology
Signal Transduction physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9327
- Volume :
- 38
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Molecular and cellular neurosciences
- Publication Type :
- Academic Journal
- Accession number :
- 18562209
- Full Text :
- https://doi.org/10.1016/j.mcn.2008.05.001