Photocytotoxicity of platinum(IV)-chloride surface modified TiO2 irradiated with visible light against murine macrophages.

Authors :: Jańczyk A
Wolnicka-Głubisz A
Urbanska K
Stochel G
Macyk W
Source :: Journal of photochemistry and photobiology. B, Biology [J Photochem Photobiol B] 2008 Jul 24; Vol. 92 (1), pp. 54-58. Date of Electronic Publication: 2008 May 13.
Publication Year :: 2008
Abstract: Phototoxicity of titanium dioxide modified with platinum(IV)-chloride complexes, [TiO2/PtCl4], irradiated with visible light was tested on murine macrophage cell line (RAW 264.7) in vitro. Presence of antioxidants such as alpha-tocopherol or beta-carotene during photodynamic treatment significantly increased cells viability. Our results indicate that observed cell death induced by [TiO2/PtCl4] was due to photogeneration of reactive species.

Subjects :: Animals
Cell Line
Light
Macrophages cytology
Macrophages metabolism
Macrophages radiation effects
Mice
Photochemistry
Macrophages drug effects
Platinum Compounds pharmacology
Titanium pharmacology
alpha-Tocopherol metabolism
beta Carotene metabolism

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