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Long-term expressional changes of Na+ -K+ -Cl- co-transporter 1 (NKCC1) and K+ -Cl- co-transporter 2 (KCC2) in CA1 region of hippocampus following lithium-pilocarpine induced status epilepticus (PISE).
- Source :
-
Brain research [Brain Res] 2008 Jul 24; Vol. 1221, pp. 141-6. Date of Electronic Publication: 2008 Apr 27. - Publication Year :
- 2008
-
Abstract
- NKCC1 and KCC2 are encoded by slc12 gene family and involved in the maintenance of intracellular chloride concentration which may be associated with epileptogenesis. In this study, we aimed to investigate the long-term expression profiles of NKCC1 and KCC2 in CA1 region in the mice model of lithium-pilocarpine induced status epilepticus (PISE) and their relationship with epileptogenesis. We found NKCC1 mRNA and proteins were up-regulated at 1 d, 14 d and 45 d after pilocarpine injection, while KCC2 was down-regulated. According to obtained results, there were some expressional changes of NKCC1 and KCC2. Deregulation of their expression may break the balance of intracellular and extracellular chloride concentration which contributes to the mechanism of hyperexcitability leading to seizures. Also it may provide new drug targets for development of new antiepileptic medicine.
- Subjects :
- Animals
Chloride Channels drug effects
Chloride Channels metabolism
Chlorides metabolism
Disease Models, Animal
Epilepsy chemically induced
Epilepsy physiopathology
Gene Expression Regulation drug effects
Gene Expression Regulation physiology
Hippocampus drug effects
Hippocampus physiopathology
Lithium Compounds pharmacology
Male
Membrane Potentials drug effects
Membrane Potentials physiology
Mice
Mice, Inbred BALB C
Muscarinic Agonists toxicity
Neurons drug effects
Neurons metabolism
Pilocarpine toxicity
RNA, Messenger drug effects
RNA, Messenger metabolism
Sodium-Potassium-Chloride Symporters drug effects
Sodium-Potassium-Chloride Symporters genetics
Solute Carrier Family 12, Member 2
Status Epilepticus chemically induced
Status Epilepticus physiopathology
Symporters drug effects
Symporters genetics
Time Factors
Up-Regulation drug effects
Up-Regulation physiology
K Cl- Cotransporters
Epilepsy metabolism
Hippocampus metabolism
Sodium-Potassium-Chloride Symporters metabolism
Status Epilepticus metabolism
Symporters metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0006-8993
- Volume :
- 1221
- Database :
- MEDLINE
- Journal :
- Brain research
- Publication Type :
- Academic Journal
- Accession number :
- 18550034
- Full Text :
- https://doi.org/10.1016/j.brainres.2008.04.047