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The role of AMG-531 in the treatment of thrombocytopenia in idiopathic thrombocytopenic purpura and myelodysplastic syndromes.
The role of AMG-531 in the treatment of thrombocytopenia in idiopathic thrombocytopenic purpura and myelodysplastic syndromes.
- Source :
-
Expert opinion on biological therapy [Expert Opin Biol Ther] 2008 Jul; Vol. 8 (7), pp. 1021-30. - Publication Year :
- 2008
-
Abstract
- Thrombocytopenia can be seen in a variety of disease states, including immune mediated thrombocytopenic purpura (ITP) and myelodysplastic syndromes (MDS). The most concerning complication is the development of hemorrhagic complications that may contribute to patient morbidity and mortality. The ligand thrombopoeitin (TPO) and its interaction with its receptor (c-mpl) are important in platelet production. Thrombopoietic agonists can help in the management of thrombocytopenia related to these conditions. Amgen Megakaryopoiesis Protein 531 (AMG-531) (Romiplostim) is a recombinant TPO with a peptide fragment that shares no sequence homology with endogenous TPO, preventing the production of neutralizing antibodies. Recent studies have shown that it is effective in raising platelet counts, and is well tolerated in ITP and MDS patients. In this review, we discuss thrombopoiesis regulation by TPO; the chemistry, pharmacokinetics and pharmacodynamics of AMG-531 in animals and humans; the pathophysiological mechanisms leading to thrombocytopenia in ITP and MDS; and clinical trials demonstrating its efficacy in treating thrombocytopenia.
- Subjects :
- Animals
Blood Platelets metabolism
Clinical Trials as Topic
Humans
Infusions, Intravenous
Models, Biological
Platelet Count
Receptors, Thrombopoietin metabolism
Recombinant Fusion Proteins
Recombinant Proteins chemistry
Treatment Outcome
Carrier Proteins therapeutic use
Myelodysplastic Syndromes therapy
Purpura, Thrombocytopenic, Idiopathic therapy
Receptors, Fc therapeutic use
Thrombocytopenia therapy
Thrombopoietin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1744-7682
- Volume :
- 8
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Expert opinion on biological therapy
- Publication Type :
- Academic Journal
- Accession number :
- 18549331
- Full Text :
- https://doi.org/10.1517/14712598.8.7.1021