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[Thyroid hormones and muscle phenotype: involvement of new signaling pathways].
- Source :
-
Journal de la Societe de biologie [J Soc Biol] 2008; Vol. 202 (2), pp. 93-100. Date of Electronic Publication: 2008 Jun 13. - Publication Year :
- 2008
-
Abstract
- Thyroid hormones (TH) are known to control development, body and muscle growth, as well as to determine muscle phenotype in the adult. TH affect muscle properties through nuclear receptors; they act either by a positive or a negative control on target genes that encode proteins accounting for contractile or metabolic phenotypes. Contractile activity and muscle load also affect muscle phenotype; several intracellular signaling pathways are involved in the transduction of signals related to contractile activity, including the calcineurin/NFAT pathway. Calcineurin activity is negatively controlled by MCIP-1 protein (modulatory calcineurin-interacting protein-1). We recently performed an experiment aimed at examining the specific and combined effects of the pharmacological calcineurin inhibition (using cyclosporin-A CsA administration) and thyroid hormone deficiency. The expected effects of CsA administration were only observed if TH were available, while thyroid deficiency totally blunted the muscle responses to calcineurin inhibition. In conditions of thyroid hormone deficiency, there was no response to the pharmacological inhibition of calcineurin, usually known to induce a slow-to-fast IIA transition associated with an enhancement of mitochondrial biogenesis in normothyroid rats. Moreover, thyroid deficiency markedly decreased the expression of MCIP-1 and MCIP-2 mRNA and proteins, two endogenous calcineurin inhibitors; such results clearly suggest that thyroid hormone and calcineurin pathways are interconnected.
- Subjects :
- Animals
Calcineurin physiology
Calcineurin Inhibitors
Cyclosporine pharmacology
DNA-Binding Proteins
Humans
Intracellular Signaling Peptides and Proteins physiology
Muscle Contraction
Muscle Development
Muscle Proteins physiology
NFATC Transcription Factors physiology
Thyroid Hormones deficiency
Muscle, Skeletal physiology
Phenotype
Signal Transduction physiology
Thyroid Hormones physiology
Subjects
Details
- Language :
- French
- ISSN :
- 1295-0661
- Volume :
- 202
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal de la Societe de biologie
- Publication Type :
- Academic Journal
- Accession number :
- 18547505
- Full Text :
- https://doi.org/10.1051/jbio:2008011