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Synthesis of 7a-substituted Hajos-Wiechert ketone analogues.
- Source :
-
The Journal of organic chemistry [J Org Chem] 2008 Jul 04; Vol. 73 (13), pp. 5151-4. Date of Electronic Publication: 2008 Jun 10. - Publication Year :
- 2008
-
Abstract
- A general and efficient route to 2-substituted 1,3-cyclopentadiones 3 has been developed. This operationally simple, two-step procedure is amenable to multigram scale preparations of these useful synthetic intermediates. These compounds are then transformed to previously unknown, higher analogues of the Hajos-Parrish-Eder-Sauer-Wiechert ketone (enone 1, R = Me) following an enantioselective Robinson annulation.
Details
- Language :
- English
- ISSN :
- 1520-6904
- Volume :
- 73
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 18540678
- Full Text :
- https://doi.org/10.1021/jo800638s