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[Small-cell variant of CD30+ -anaplastic large-cell lymphoma of the skin].
- Source :
-
Arkhiv patologii [Arkh Patol] 2008 Mar-Apr; Vol. 70 (2), pp. 40-3. - Publication Year :
- 2008
-
Abstract
- Three cases of the so-called variant of primary cutaneous CD30+ anaplastic large cell lymphoma (ALCL) are presented. All patients were males aged 52, 59, and 78 years old; they had a solitary cutaneous tumor nodule. Their sites included the axilla, thigh, and shoulder. There was no extracutaneous involvement. Microscopically, the tumors were composed of small cells with irregular nuclei that were immunohistochemically positive for CD3, CD5, CD7, and CD30 and negative for B-cell markers; there was focal ALK-1 positivity in 1 case. Two cases had CD4+/CD8-phenotype, while the remaining one exhibited a CD4-/CD8+ immunoprofile. Fhedium to large CD30+ cells were rarely found scattered in the infiltrate. Monoclonal TCR gamma gene rearrangement was detected in 2 cases and rearrangement of IgH (lineage infidelity) was in one case. The tumors were surgically removed in all the patients. Two patients were alive and well 4 and 6 years after surgery, without evidence of cutaneous and extractaneous involvement (including the ALK+ patient). The third patient experienced several relapses of the skin tumor and developed axillary and inguinal lymph node involvement. Chemotherapy was performed and finally the patient underwent allogenic bone marrow transplantation; he died 3 years after the original diagnosis due to acute graft-versus-host disease and sepsis.
- Subjects :
- Aged
Antigens, CD immunology
Cell Size
Gene Rearrangement, B-Lymphocyte immunology
Gene Rearrangement, T-Lymphocyte immunology
Humans
Immunoglobulin Heavy Chains immunology
Lymphoma, Large B-Cell, Diffuse immunology
Lymphoma, Large B-Cell, Diffuse surgery
Male
Middle Aged
Receptors, Antigen, T-Cell immunology
Skin Neoplasms immunology
Skin Neoplasms surgery
Ki-1 Antigen
Lymphoma, Large B-Cell, Diffuse pathology
Skin Neoplasms pathology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0004-1955
- Volume :
- 70
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Arkhiv patologii
- Publication Type :
- Academic Journal
- Accession number :
- 18540441